Question 1

Eukaryotic transcription promoters

Accepted Answer

A)   require multiple DNA binding regions.
B)   are largely conserved across the genome.
C)   can stimulate DNA polymerases by direct binding.
D)   control translational as well as transcriptional events.E) C) and D)
F) B) and C)

Question 2

Which is NOT required in the prokaryotic transcription initiation complex?

Accepted Answer

A)   a primer
B)   RNA polymerase
C)   initiation factor
D)   a ribonucleotide triphosphate (NTP) E) All of the above
F) C) and D)

Question 3

Describe the composition and processing of the C-terminal domain (CTD)of eukaryotic RNA polymerase II,as well as its role in transcription.

Accepted Answer

The CTD is a repeating peptide sequence ...

Question 4

Group I and group II introns are similar in their

Accepted Answer

A)   requirement for metal ion cofactors.
B)   requirement for exogenous nucleoside binding.
C)   DNA composition.
D)   intron lariat structure.E) None of the above
F) A) and C)

Question 5

Describe two ways that termination can occur in the transcription of prokaryotic genes.

Accepted Answer

(1)The protein Rho binds to a C-rich reg...

Question 6

A knockout mutation in the X-inactive specific transcript (XIST) lncRNA of mice would result in

Accepted Answer

A)   one inactivated X chromosome in female mice.
B)   the inhibited transcription and translation of X-linked proteins.
C)   two inactive X chromosomes in female mice.
D)   two active X chromosomes in female mice.E) A) and C)
F) A) and B)

Question 7

Eukaryotic RNA polymerase

Accepted Answer

A)   is a ribozyme.
B)   contains as many as five protein subunits in the final functional enzyme.
C)   synthesizes all RNA types.
D)   has a common core structure resembling that of prokaryotic RNA polymerase.E) A) and D)
F) B) and C)

Question 8

The initiation of transcription in eukaryotes

Accepted Answer

A)   occurs in the same manner as prokaryotic transcription.
B)   requires the complete unfolding of the gene into single-stranded DNA.
C)   requires many more transcription factors than prokaryotic transcription.
D)   uses RNA polymerase as well as helicase and primase.E) A) and B)
F) A) and C)

Question 9

The enzyme responsible for making siRNA is

Accepted Answer

A)   RISC.
B)   snoRNA.
C)   exosome.
D)   dicer.E) A) and C)
F) None of the above

Question 10

Eukaryotic promoters,but NOT prokaryotic promoters,

Accepted Answer

A)   are located before the transcription start site.
B)   bind transcription factors.
C)   are located after the transcription start site.
D)   assist in activating transcription.E) None of the above
F) B) and C)

Question 11

What are  factors in RNA synthesis?

Accepted Answer

A)   DNA promoter regions
B)   RNA polymerases
C)   transcription factors
D)   receptor proteinsE) C) and D)
F) None of the above

Question 12

Which enzyme is responsible for adding the poly(A) tail to mRNA?

Accepted Answer

A)   cleavage stimulatory factor (CStF) 
B)   poly(
A)   polymerase
C)   cleavage and polyadenylation specificity factor (CPSF) 
D)   poly(
A)   binding proteinE) A) and D)
F) B) and D)

Question 13

Why must tRNA contain base modifications?

Accepted Answer

tRNAs have very similar second...

Question 14

Approximately how many different types of RNA promotors are needed in eukaryotic systems?

Accepted Answer

A)   1
B)   2
C)   3
D)   4E) None of the above
F) A) and C) C

Question 15

Which is the correct order of mRNA degradation?

Accepted Answer

A)   (1)  poly(
A)   tail removal; (2)  7-methylguanosine cap removal; (3)  RNA hydrolysis
B)   (1)  7-methylguanosine cap removal; (2)  RNA hydrolysis; (3)  poly(
A)   tail removal
C)   (1)  7-methylguanosine cap removal; (2)  poly(
A)   tail removal; (3)  RNA hydrolysis
D)   (1)  RNA hydrolysis; (2)  Poly(
A)   tail removal; (3)  7-methylguanosine cap removalE) B) and C)
F) C) and D)

Question 16

Long noncoding RNA (lncRNA) is generated from

Accepted Answer

A)   the tips of chromosomes.
B)   the transcription of genomic DNA.
C)   the splicing of used mRNA.
D)   an infection of viral RNA.E) B) and C)
F) C) and D)

Question 17

The spliceosome

Accepted Answer

A)   is a cis-acting ribozyme.
B)   resembles group II introns in its mechanism and product.
C)   performs the same function in prokaryotes and eukaryotes.
D)   is a protein enzyme.E) C) and D)
F) All of the above B

Question 18

Antisense RNA binds to __________ and sense RNA binds to __________.

Accepted Answer

A)   template DNA; coding DNA
B)   tRNA; mRNA
C)   coding DNA; template DNA
D)   mRNA; coding DNAE) A) and B)
F) A) and C) A

Question 19

Which of the following is a coding RNA molecule?

Accepted Answer

A)   short interfering RNA.
B)   TERC RNA.
C)   small nucleolar RNA.
D)   messenger RNA.E) B) and C)
F) None of the above

Question 20

A 7-methylguanylate cap and poly(A) tail is added to mRNA to

Accepted Answer

A)   differentiate the mRNA from the tRNA.
B)   facilitate binding and translation by the ribosome.
C)   increase mRNA splicing efficiency.
D)   signify the start and end of the gene sequence.E) C) and D)
F) B) and C)

Exam 21: Rna Synthesis, processing, and Gene Silencing

Eukaryotic transcription promoters

Correct AnswerverifiedShow Answer

Which is NOT required in the prokaryotic transcription initiation complex?

Correct AnswerverifiedShow Answer

Describe the composition and processing of the C-terminal domain (CTD)of eukaryotic RNA polymerase II,as well as its role in transcription.

Correct AnswerverifiedThe CTD is a repeating peptide sequence ...View AnswerShow Answer

Group I and group II introns are similar in their

Correct AnswerverifiedShow Answer

Describe two ways that termination can occur in the transcription of prokaryotic genes.

Correct Answerverified(1)The protein Rho binds to a C-rich reg...View AnswerShow Answer

A knockout mutation in the X-inactive specific transcript (XIST) lncRNA of mice would result in

Correct AnswerverifiedShow Answer

Eukaryotic RNA polymerase

Correct AnswerverifiedShow Answer

The initiation of transcription in eukaryotes

Correct AnswerverifiedShow Answer

The enzyme responsible for making siRNA is

Correct AnswerverifiedShow Answer

Eukaryotic promoters,but NOT prokaryotic promoters,

Correct AnswerverifiedShow Answer

What are factors in RNA synthesis?

Correct AnswerverifiedShow Answer

Which enzyme is responsible for adding the poly(A) tail to mRNA?

Correct AnswerverifiedShow Answer

Why must tRNA contain base modifications?

Correct AnswerverifiedtRNAs have very similar second...View AnswerShow Answer

Approximately how many different types of RNA promotors are needed in eukaryotic systems?

Correct AnswerverifiedC

Which is the correct order of mRNA degradation?

Correct AnswerverifiedShow Answer

Long noncoding RNA (lncRNA) is generated from

Correct AnswerverifiedShow Answer

The spliceosome

Correct AnswerverifiedB

Antisense RNA binds to __________ and sense RNA binds to __________.

Correct AnswerverifiedA

Which of the following is a coding RNA molecule?

Correct AnswerverifiedShow Answer

A 7-methylguanylate cap and poly(A) tail is added to mRNA to

Correct AnswerverifiedShow Answer

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The CTD is a repeating peptide sequence ...
View Answer

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(1)The protein Rho binds to a C-rich reg...
View Answer

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tRNAs have very similar second...
View Answer

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C

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B

Antisense RNA binds to and sense RNA binds to .

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A

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