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What is the primary mechanism of action of clomiphene as a synthetic ovulation stimulant?


A) As an estrogen agonist that inhibits negative feedback to the anterior pituitary
B) As an estrogen agonist that promotes negative feedback to the anterior pituitary
C) As an estrogen antagonist that inhibits negative feedback to the anterior pituitary
D) As an estrogen antagonist that promotes negative feedback to the anterior pituitary

E) A) and B)
F) C) and D)

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What is the role of nitric oxide (NO) in establishing and maintaining an erection?


A) NO produces cyclic guanosine monophosphate.
B) NO metabolizes cyclic guanosine monophosphate.
C) NO blocks phosphodiesterase type 5.
D) NO stimulates the enzyme guanylatecyclase.

E) A) and B)
F) A) and C)

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Sperm production is enhanced through the synergistic interaction between _____.


A) GnRH and DHEA
B) GnRH and testosterone
C) testosterone and FSH
D) testosterone and LH

E) A) and B)
F) B) and C)

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Which of the following is a contraindication to the use of estrogens and progestins in women?


A) Hypotension
B) Liver disease
C) Diabetes
D) Sexual activity

E) A) and D)
F) All of the above

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Which of the following is not a risk associated with long-term HRT in women?


A) Heart attack
B) Osteoporosis
C) Stroke
D) Breast cancer

E) B) and C)
F) A) and B)

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How does arteriosclerosis cause erectile dysfunction?


A) By altering psychomotor activity
B) By potentiating nerve excitability
C) By reducing the flow of blood throughout the body, including the penis
D) By decreasing the formation of clotting factors

E) B) and C)
F) All of the above

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Which of the following clinical conditions has shown an improvement with hormone replacement therapy?


A) Osteoporosis
B) Dysmenorrhea
C) Infertility
D) Diabetes

E) A) and B)
F) B) and C)

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Which of the following is an adverse effect caused by the chronic use of testosterone in adult males?


A) Reduced sperm count
B) Hirsutism
C) Acne
D) Stunting of bone growth

E) A) and B)
F) B) and C)

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Apart from individual patient risk factors,which of the following pairs of factors is associated with the potential for adverse effects during hormone replacement therapy?


A) Dose and increased prothrombin levels
B) Increased prothrombin levels and length of treatment
C) Dose and length of treatment
D) Hypertension and hypercholesterolemia

E) C) and D)
F) A) and B)

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Which of the following pairs of hormones is released from the anterior pituitary?


A) FSH and LH
B) FSH and GnRH
C) LH and estrogen
D) LH and GnRH

E) A) and B)
F) C) and D)

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The most effective treatment for relief of hot flashes,sleep disturbances,and vaginal dryness is _____.


A) oral contraceptives
B) clomiphene
C) hormone replacement therapy
D) androgen therapy

E) C) and D)
F) None of the above

Correct Answer

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Which of the following hormones has an inhibitory effect on endometrial muscle contractions?


A) Estriol
B) Estradiol
C) Estrone
D) Progesterone

E) B) and C)
F) A) and B)

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Hormone replacement therapy is used to treat dyspareunia,a condition in which:


A) complete cessation of a menstrual period occurs.
B) there is a significant decrease in female sex hormone production.
C) body and facial hair is excessive.
D) vaginal atrophy may cause difficult or painful sexual intercourse.

E) A) and B)
F) A) and D)

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Which of the following is a clinical indication for the use of androgens in women?


A) Oral contraception
B) Fertility enhancement
C) Metastatic inoperable breast cancer
D) Hormone replacement therapy

E) C) and D)
F) A) and B)

Correct Answer

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Which naturally occurring estrogen is the most abundant and active in the female body?


A) Progesterone
B) Estrone
C) Estradiol
D) Estriol

E) A) and C)
F) None of the above

Correct Answer

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