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What process generates many B cells and T cells that are activated against specific antigens?


A) Antigen expression
B) Antigen presentation
C) Clonal expansion
D) Antibody production
E) Opsonization

F) All of the above
G) D) and E)

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The major histocompatibility complex is


A) a set of glycoproteins, called MHC antigens, found on all body cells.
B) a set of genes that code for MHC glycoproteins.
C) found on the third chromosome.
D) located in the thymus gland.
E) All of the choices are correct.

F) None of the above
G) A) and C)

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Small foreign molecules that are too small by themselves to elicit an immune response are termed ______.


A) haptens
B) antigen binding sites
C) epitopes
D) variable regions

E) C) and D)
F) B) and C)

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The adaptive immune response differs from the innate response in that


A) memory.
B) B and T lymphocytes can each target multiple proteins, whereas the innate response targets only a single type of antigen.
C) the adaptive immune response involves physical barriers and nonspecific processes, whereas the innate immune response relies on the actions of B and T lymphocytes.
D) the innate immune response targets a specific immunogen and remembers it to mount an even stronger response on subsequent encounters with that immunogen, whereas the adaptive response is nonspecific and has no memory.

E) A) and B)
F) A) and C)

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Antitoxins


A) are always genetically engineered.
B) confer passive immunity.
C) contain select antigenic components of a pathogen rather than whole cells or viruses.
D) utilize DNA strands that will produce the antigen.
E) contain modified bacterial exotoxin molecules.

F) D) and E)
G) B) and D)

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An example of artificial passive immunity would be


A) chickenpox infection, followed by lifelong immunity.
B) chickenpox vaccine triggering extended immunity to chickenpox.
C) giving a person immune serum globulins to chickenpox virus after exposure to the disease.
D) a fetus acquiring maternal IgG to the chickenpox virus across the placenta.

E) None of the above
F) A) and C)

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Autoimmune disorders are characterized by immune destruction of self tissues.The underlying basis of these disorders is


A) lack of an anamnestic response.
B) an overproduction of complement.
C) a lack of immune tolerance.
D) an oversecretion of antibodies from memory B cells.

E) A) and B)
F) B) and D)

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The array of potential antibodies to the variety of possible antigens is amazing.Which statement explains this development?


A) Mutations in the antibody gene occur within the activated B cells, since they meet the antigen.
B) The existing antibody molecules change their shapes, allowing them to fit with a large number of antigens.
C) There is a shuffling of genes that code for self markers as well as nonself markers, mixing them together and producing reactive lymphocytes to those markers.
D) Recombination of genes coding for the variable regions of immunoglobulins occurs during the developmental stage of lymphocyte production.

E) All of the above
F) None of the above

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Clonal selection requires the presence of foreign antigens.

A) True
B) False

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The immunoglobulin class that is the only one capable of crossing the placenta is ______.


A) IgA
B) IgG
C) IgM
D) IgD
E) IgE

F) A) and D)
G) A) and C)

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The hinge region of an antibody has a hypervariable amino acid region where the antigenic determinant fits.

A) True
B) False

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Human B lymphocytes mature in an intestinal region called the bursa.

A) True
B) False

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The most abundant class of antibodies in serum is _____.


A) IgE
B) IgM
C) IgA
D) IgG
E) IgD

F) A) and E)
G) A) and D)

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